Acute sulphasalazine hepatotoxicity.

Acute sulphasalazine hepatotoxicity.

We describe a case of severe sulphasalazine hepatotoxicity. The features described are those of an acute hypersensitivity reaction which responded to drug withdrawal alone as steroids were withheld. Supportive treatment only is recommended for this potentially fatal condition.

Sulphasalazine hepatotoxicity: lack of a hypersensitivity response.

Sulphasalazine associated pancytopenia may be caused by acute folate deficiency.

Agranulocytosis and aplastic anaemia associated with sulphasalazine are well recognised, but pancytopenia caused by acute megaloblastic arrest of haemopoiesis while taking sulphasalazine has not previously been described. We report three patients who, after taking sulphasalazine for over two years, suddenly developed severe pancytopenia with gross megaloblastic changes in the marrow. In two pat...

Low-dose cyclophosphamide-induced acute hepatotoxicity

PATIENT Male, 48 FINAL DIAGNOSIS: Low dose cyclophosphamide-induced acute hepatotoxicity Symptoms: Epigastric pain Medication: Withdrawal of cyclophosphamide Clinical Procedure: - Specialty: Nephrology • Hepatology • Gastroenterology • Toxicology. OBJECTIVE Unexpected drug reaction. BACKGROUND Cyclophosphamide is commonly used to treat cancers, systemic vasculitides, and kidney diseases (e....

Sulphasalazine in ankylosing spondylitis.

In recent years sulphasalazine has gained acceptance as an effective agent for the treatment of rheumatoid arthritis. Ankylosing spondylitis is a disease where remission inducing drugs so far have been lacking. In this double blind trial sulphasalazine was compared with placebo in 37 patients with ankylosing spondylitis. Evaluation after three months' treatment showed reduction of inflammatory ...